The increasing aggravation of oncological diseases among the population of the Kirovohrad region was analyzed. Two types of causes of malignant neoplasms: internal (genetic predisposition, genetic factors, the immune system of the organism, etc.) and external (carcinogenic environmental factors) was found. Statistical information of oncological diseases in the region was analyzed. An adverse effect on the oncoepidemiological situation of uranium deposits and radon were characterized. Also the program of regulating the quantity of radon, «Stop radon», was considered. The «Stop radon» program was carried out in 2012. Amount of radon in the premises exceeded the norm by 2-3 times. But this program was discontinued due to lack of funds in 2013. Cancer is not a single disease with a single cause or treatment. It develops when cells in the body grow in an uncontrolled and abnormal way. There are numerous types of cancer, each with its own name and treatment and different types of cancer have their different sets of causes. An individual’s risk of developing a cancer is influenced by a combination of factors including personal habits such as smoking and alcohol consumption, genetics, personal characteristics such as sex (male or female), ethnicity, age, exposure to carcinogens in the environment and so on. In particular, excessive smoking causes lung cancer, unbalanced diet leads to stomach cancer and the amount of solar radiation is the cause of skin cancer, etc. Every year oncoepidemiological situation in the Kirovohrad region is increasingly aggravated. There is also the concept of «occupational cancer». Occupational cancer is caused by exposure to carcinogens in the workplace. Also the scale of occupational cancer spread within the region was analyzed. The highest numbers of cases of occupational cancer are in the Kirovohrad, Dnipropetrovsk, Luhansk, Donetsk and Zaporizhia regions. The government of Ukraine must develop programs to fight against occupational cancer. Keywords: malignant neoplasms, uranium deposits, radon, oncoepidemiological situation, occupational cancer.