Historical and geographical division into districts is a poorly developed section of regional history geography. The author considers several factors that influence upon this type of division into districts of the regional nature-use. Seven stages in the development of forming the regional nature-use in the region were identified. The scheme of historical and geographical division of South-East Ukraine is included, and the district division units are briefly characterized.
Key words: South-East Ukraine region, frontier of region, the historical geography stages of development of the regional nature-use.